Numerous skills involving the introduction of (OP) opposed piston engine have been developed in the recent past. Indeed, novel techniques can help to improve the performance of the engine. The aim of this paper is to model and simulate a simple single-cylinder two-stroke opposed-piston engine and minimise fuel consumption and heat loss, using the software programme AVL BOOST™. AVL BOOST is an engine modelling software, which analyses the performance of a modelled single cylinder two-stroke opposed-piston engine by changing desired parameters. In order to meet this aim, experimental results from a unique engine are used to make a comparison with the results obtained from AVL BOOST model. Six combinations of compression ratios (12, 13.5, 15, 16.5, 18 and 19.5) are analysed in this study with the engine speed running at 420 rpm and 1500 rpm. In addition to the compression ratios, the effect of stroke-to-bore (S/B) ratios on OP2S performance is investigated. Various values of S/B ratios, whilst maintaining a constant swept volume, port geometry and combustion timing, and their effect on fuel consumption and heat loss are analysed in this study. A comparison between the two engine speeds with increasing combinations of compression ratios, and the S/B ratios revealed minimal differences in peak pressure, peak temperature, IMEP, ISFC, indicated efficiency and total heat loss. Detailed analyses of these parameters are highlighted in discrete sections of this paper.